I did a 45 mile ride without taking these and my legs started cramping around mile 35, mostly due to my refusal to eat & drink enough no matter how many times it happens. The next day I went out again but remembered to bring some of these with me, about 12 miles into a 33 mile ride with constant wind in my face and countless hills my legs started to feel like they might start cramping again. The only thing I did differently than usual was take 2 of these pills and I did not cramp up, I did try to make an effort to eat and drink more but it wasn't that much more than I typically consume.
I use these for events where the is supplied via my camel pack. Putting sugary electrolyte mixes in the camel pack is a quick way to ruin a bladder. I can carry several of these in my kit and take in timed intervals to supplement my electrolytes. Worked like a champ for the Dirty Kanza!
Had serious problems with cramping during gravel races. Thought Id give these a try typically 2 tabs prior to start, then 1-2 tabs Q 1-4 hours depending temperature and exertion. Now Im standing on the podium. Not really, but at least Im not cramping.