Orange Seal is an excellent worry-free sealant for all types of tubeless applications. I have ran it in several tubeless setups, and have never had an issue with the sealant sealing any holes. I keep these 4 ounce injectors with me in the rare event I neglect sealant maintenance, so that I can add it roadside. The Endurance formula is fantastic as it lasts longer (doesn't dry up as quickly), but note that it does not seal as large of holes as the Original formula. Regardless, I've never had an issue with any Orange Seal product, and I run it confidently both on and off-road. I ride 10,000 to 20,000 miles a year, and would never consider going back to a tubed system as long as Orange Seal is around. HIGHLY recommended.